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Systems Level Studies of Mammalian Metabolomes: The Roles of Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy

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First, it is possible that both interventions converge on similar metabolic pathways, such as improved mitochondrial function, reduction of oxidative stress, and enhancement of cardiac energy efficiency, thereby reaching a ceiling effect beyond which no further benefit is observed

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However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs