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Furthermore, recent studies show the benefits of tirzepatide in people with metabolic dysfunctionassociated steatohepatitis (MASH) [5], in people with heart failure with preserved ejection fraction (HFpEF) and obesity [6], and in people with T2D with established atherosclerotic cardiovascular disease according to a recent press release [7]

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SREBP-1, in particular, governs the transcription of various lipogenic enzymes, including ACC, FASN, and glucose-6-phosphate dehydrogenase (6PGD), thereby playing a critical role in fatty acid biosynthesis [25]