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Size, surface charge, and flexibility are important determinants for cellular internalization of NPs, with lipid-based NPs being more readily internalized than rigid silica or metal-based NPs (12, 13)

In a Regulatory Affairs Report from 2018, Coppens states: After the adoption of the Food Supplements Directive 2002/46, the Commission published a report in 2008 on further harmonization in this area (Commission of the European Communities, 2008)

Astrocytes were prepared from the mixed brain cell cultures using a protocol previously described by Guillemin et al

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