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INTRODUCTION Ethics statement Ethics approval was not required for this in vitro study, as it did not involve human participants, identifiable human data, or animal subjects

Melanotan-2 enhances libido by activating melanocortin-4 receptors (MC4R) in the paraventricular nucleus of the hypothalamus and melanocortin-3 receptors (MC3R) in limbic structures, triggering dopamine release and nitric oxide synthesis in neural pathways that govern sexual arousal and spontaneous erection