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There are differences in how effectively these vitamins perform their functions in people with Down syndrome compared to people without Down syndrome

The design logic is that skin and connective-tissue outcomes are rarely limited by one pathway

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Diagnosis uses tests such as barium swallow, upper endoscopy (esophagogastroduodenoscopy or EGD), and esophageal manometry to evaluate motility

, 26 , 509-522.e6 (2017)