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Data suggest the requirement of GLP1 receptors in both the vagal afferents as well as the brain for the full effects of GLP1 receptor agonists on energy balance, with the hypothalamus being the primary downstream target of peripherally administered GLP1 receptor agonists
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Reports that DPP-4 may be associated with glucagon in the secretory granules of the pancreatic -cell first emerged in 1993, when positive staining in pig islets was shown using immunohistochemical and enzyme histochemical techniques ( Dpp4 expression
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