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This reflects normal metabolism of creatine and does not necessarily indicate kidney damage

The most commonly observed adverse events (incidence of 5% and twice that of placebo) were oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation and fecal incontinence

These medications work through several mechanisms: Slowed gastric emptying food stays in the stomach longer before moving to the intestines