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Overall, 4 malignancies were reported in OPERA 1 trial in RRMS patients and 11 malignancies were reported in PPMS patients in the ORATORIO trial (70)

A deficiency in L-arginine can contribute to high blood pressure and an increased risk of cardiovascular disease

Sun, J., Feng, Q., He, Y., Wang, M

Peter Friedlander Title: Head of Global TV, Amazon MGM Studios Held job since: 2025 Sources of power: He spent 14 years at Netflix, overseeing its first wave of original series including House of Cards, Orange Is the New Black and Narcos. Hes well-regarded for his taste and the shows and creators he championed during Netflixs formative years in original content

Following a comprehensive cellular and cytokine profiling by flow cytometry across distinct immunological niches, we identified CD4 + T cells residing in the dural meninges as a source of disease-associated IL-17A in 5xFAD mice, which was downregulated by targeting CD38, with no effect on IFN-- or IL-4-producing T cells (Fig