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Understanding the role of GLP-1 RA in PWS may offer a new and effective therapeutic opportunity for a condition still orphan of an evidence-based recommendation for the treatment of PWS with obesity and type 2 diabetes

The hypothalamic-pituitary-ovarian axis, which regulates the menstrual cycle, is highly sensitive to changes in body composition, nutritional status, and metabolic signals

Experimental receptor assays demonstrate that GLP-RTfunctions as an agonist at all three receptors, although the peptide exhibits differing potency levels across the receptor set

References Khavinson, V