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For example, a meta-analysis conducted in 2023, which analyzed data from 1,137,044 patients, found that the relative risk of developing HF for every 5-unit (kg/m2) increase in body mass index (BMI) was 1.42 [95% CI, 1.401.44] [3]

Individuals with pre-existing conditions such as chronic kidney disease , type 1 diabetes , or inflammatory bowel disease should exercise particular caution, as dehydration and electrolyte disturbances can have more serious consequences in these groups

Research indicates that gut microbial metabolites, such as SCFAs and -tocopherol, can activate various G protein-coupled receptors (e.g., FFAR2, OLF78, GPBAR1) on the surface of EC cells, thereby promoting the expression of tryptophan hydroxylase 1 (TPH1) and the release of 5-HT (252255)

Why Personalization is Paramount Every body reacts differently to metabolic changes