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If we block that signal and override it with medication, it doesnt stop the signal - it just redirects it

The goal shifts from weight loss to weight maintenance and continued metabolic health

Last reviewed: June 23, 2026 Last updated: June 23, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

272 Further investigation is critical to understand the health implications of specific nutritional and microbiome interventions on endogenous GLP-1 secretion

Some people mainly experience early fullness, bloating, upper abdominal discomfort, heartburn, belching, or poor appetite