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To chemoenzymatically synthesize selective cathepsin C inhibitor E-64c hydrazide, a large-scale 40-ml reaction in 50 mM sodium phosphate buffer (pH 8.0) containing 5 mM ()- t -ES, 2.5 mM l-norleucine ( a3 ), 2.5 mM tryptamine ( b44 ), 2.5 M Cp1B and 2.5 M Cp1D was carried out at 30 C for 16 h

Furthermore, a 28-day feeding study of SD rats showed that L-theanine could increase the content of total short-chain fatty acids and regulate intestinal mucosal immunity based on dietary fiber feeding (95)

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