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It is available as FDA-approved branded products and, separately, as compounded formulations from state-licensed 503A pharmacies

The STEP 1 trial extension study, published in Diabetes, Obesity and Metabolism , found that participants who discontinued semaglutide after 68 weeks regained approximately two-thirds of their lost weight within one year of stopping treatment

Semaglutide, a GLP-1 receptor agonist, has shown: Improved glycaemic control (HbA1c reduction) Better fasting and post-prandial glucose control Added benefit in weight management Clinical data (Phase III study with 312 participants) demonstrated comparable efficacy and safety to existing reference drugs

Increased Activity To combat a sedentary lifestyle, its important to stay active throughout the day

Both medications require lifestyle modifications, but Orlistat demands stricter dietary management to avoid unwanted side effects