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Similar findings were reported in analyses of tirzepatide, where about three-quarters of the weight loss was fat mass and one-quarter was lean mass, proportions that closely resemble those observed with diet-induced weight loss [14, 23]

Approximately 25% of total weight lost on tirzepatide was lean mass (SURMOUNT-1 DXA substudy), and in semaglutide trials, that proportion may reach up to 40% (STEP 1 DXA subset)

However, the subjective feeling of reduced hunger often takes 25 days to become noticeable as the medication reaches steady-state levels in your bloodstream