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These include the development of gallstones and acute gallbladder disease, with risks appearing to intensify for individuals using the drug at higher doses or for extended periods

The mouth was dry, with sticky mucosa and minimal frothy saliva (Fig

Adults may require higher doses of B12 because of their diet, other health issues, and medicines they take

Cancer Cell 16 , 91102 (2009)

The accumulating 1 -pyrroline-5-carboxylate can then be reduced to proline by the NADP(H)-dependent enzyme pyrroline-5-carboxylate reductase (PYCR or P5CR)