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It inhibits GPX4, leading to tumor-specific ferroptosis, and TA is used to chemically reduce Fe 3+ to Fe 2+ and continuously supply Fe 2+ to maintain the iron redox cycle and maintain the Fenton reaction [201]

Study shows that treatment with GSK864 as IDH1 inhibitor binding an allosteric site on IDH1 reduces the NADPH/NADP + ratio and prolongs the survival of glioblastoma multiforme (GBM) PDXs model

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10.1016/j.redox.2015.07.008 48 FanY.ChangY.WeiL.ChenJ.LiJ.GoldsmithS.et al (2019)