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It was approved by the FDA in 1989

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It's the period when durable habits are easiest to build, because the medication is doing the heavy lifting on appetite regulation and patients can focus on pattern and preference without fighting their own biology

So muscle loss speeds up after menopause often one to 2% per year, and that reduces our resting energy, expenditure and glucose disposal capacity

Notably, DPP-IV targets include cytokines, growth factors, and neurotransmitters, in addition to islet-derived peptide hormones, indicating that the improvements in beta-cell function in response to DPP-IV inhibition may also be mediated by other intra-islet paracrine signaling factors