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This does not mean it is illegal to possess or use for research purposes, but it cannot be marketed or sold as a treatment within the US

After deparaffinization and hydration, the sections were incubated in pepsin (Abcam, ab801437) for 10 minutes, and then in a 3% hydrogen peroxide solution for an additional 10 minutes

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Most effective depends on the goal: GHK-Cu tends to be most effective for global skin rejuvenation (texture, fine lines, recovery after procedures)