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Mathematical and microbiological evidence of negligible contamination A 2022 study mapping skin microflora and modeling needleskin interactions found that the probability of actually carrying live bacteria below the skin during a subcutaneous injection is effectively zeroand no clinical skin infections have ever been documented under these conditions (PMC)

If they help, the effect is on the gut ecosystem layer running parallel to the drug, not on the drug's pharmacology itself

Some researchers continue indefinitely, while others cycle off after reaching their weight loss goals

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