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Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease

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NADPH oxidase is a major enzyme complex involved in this response, but mitochondria also produce excessive ROS levels under hypertension

To determine the impact of MTX on cell metabolism, cell lines underwent unsupervised global metabolic profiling by 1 H-NMR in either the presence or in the absence of the drug (a representative 1 H-NMR spectrum is shown in Supplementary Figure 2 )