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Abbreviations Fe: Ferrum g: Gram GFR: Glomerular filtration rate GGT: Gamma-glutamyl transpeptidase GOT: Glutamic oxaloacetic transaminase GP: General practitioner GPT: Glutamic-pyruvic transaminase HIV: Human immunodeficiency virus HVB: Hepatitis B virus HVC: Hepatitis C virus IF: Intrinsic factor g: Microgram MMA: Methylmalonic acid mg: Milligrams ng: Nanograms pg: Picograms

If they were persistent or severe, the parents were offered the option to discontinue the study

Low levels of glutathione have been linked to various liver diseases, highlighting the importance of maintaining optimal glutathione levels for liver health

GSH plays a paramount role in brain antioxidant defense, maintaining redox homeostasis

Some Phase 3 trial sites are in Asia (REDEFINE 5, REDEFINE 6) but no regulatory approvals have been announced as of June 2026