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Vitamin E acts as a regulator of cellular metabolism, and its deficiency leads to anaemia, dysregulation of energy metabolism, irregular mitochondrial function, and tissue damage resulting from increased lipid peroxidation (170)

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This natural defense mechanism helps prevent cellular damage, but repeated exposure without protection can lead to persistent dark spots, commonly called sunspots or age spots

Another systematic review suggests that TZD drugs are associated with a reduction in the risk of liver cancer, colorectal cancer, as well as breast cancer [107]

The gut microbiota composition influences neuroinflammation and brain function