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Support Beyond Prescriptions: Guidance on lifestyle, nutrition, and next steps

While there are several reasons you may not be seeing your desired results from a GLP-1, new research points to a cause that might not be on your radar yet: your genes

The dose-limited side effects for shorter-acting agents such as exenatide, lixisenatide, and liraglutide are largely gastrointestinal in nature

These reports should be interpreted as hypothesis-generating rather than clinically confirmed adverse-effect estimates

In one study, it was demonstrated that exendin-4 prevented LPS-induced depressive-like symptoms in rats and displayed antidepressant-like properties measured in the forced swim test, but this effect was not mediated by the modulation of neuroinflammatory processes, since the levels of IL-1 and TNF- were not affected by exendin-4 treatment [67]