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413 Partial ablation of astrocytes in the prefrontal cortex of healthy rats (by injection of gliotoxin L--aminoadipic acid) resulted in the development of depressive-like behaviours, whereas injection of neurotoxin ibotenate did not have such an effect

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This requires a sleep study showing an AHI (apnea-hypopnea index, measuring breathing interruptions per hour) of 15 or higher and BMI 30

Conversely, blocking GLP-1R with the same antagonist in Sstr5 / mice worsened their otherwise improved glucose tolerance, which seemed more pronounced in Sstr5 / mice receiving Ex939 than in the Sstr5 +/+ mice receiving Ex939