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These data have highlighted a number of key data and knowledge gaps, which hopefully will be addressed in the future

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Current evidence supports regular moderate-intensity aerobic exercise (3060 min per session, 35 days per week), which reduces visceral adiposity, improves insulin sensitivity, lowers oxidative stress, increases anti-inflammatory cytokines (e.g., IL-10), and modulates immune-cell profiles (higher regulatory T-cell and lower macrophage counts), thereby attenuating systemic inflammation 50