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En su desarrollo se observan cambios como la acumulacin de placas amiloides y ovillos neurofibrilares en el cerebro, lo cual lleva a la muerte de las neuronas y al deterioro de las funciones cognitivas

At 24 weeks, mean percentage decrease in weight (primary outcome) ranged from 7.2% to 17.5% with different retatrutide doses compared with 1.6% with placebo

Moreover, all patients on GLP-1 RAs, irrespective of drug type, dose, duration of therapy, and absence of symptoms, can have delayed gastric emptying

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The ACCORD trial ended its intensive therapy early, after 3.5 years, because of a significant increase in deaths in the intensive-therapy group