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Vitamin D3 supplementation is particularly useful during colder months when natural sunlight exposure is limited

By acting as a carrier and regulator of bioavailable copper, GHK-Cu plays a role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling

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Crosstalk between microglia and astrocytes further contributes to neurodegeneration, as demonstrated by prolonged survival in SOD1 mouse model when this intracellular communication was blocked (Guttenplan et al., 2020b)

The major difference between the metabolite-driven and metabolic state-driven approaches is how to determine the metabolic reprogramming agents