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The key consideration: retatrutide does not affect testosterone production directly, but the caloric restriction it enables can suppress natural testosterone production through the HPG axis

This includes mental health deterioration, memory problems, sensory issues, and sensations of pain

After research demonstrated that people could lose up to 11% of their body weight from Ozempic, it skyrocketed in popularity as an off-label medication for weight loss

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The cold sensation is especially noticeable in the first 48 weeks of GLP-1 therapy, as your body adjusts to the new hormonal signaling