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10.1007/s00432-018-2740-3 102 NiuB.LeiX.XuQ.JuY.XuD.MaoL.et al (2022)

Current anti-obesity pharmacotherapy includes 5 FDA-approved medications: orlistat, phentermine-topiramate, naltrexone-bupropion, liraglutide, and semaglutide (Table 2), as well as phentermine, which is approved only for short term use

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Mendelian randomization evidence indicates that elevated KYN levels have a causal relationship with increased risk of depression, with each standard deviation increase in KYN corresponding to ~ 1.4-fold higher odds of developing depression [50]

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