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Cells were allowed to rest for 45 min at 37 C and 5% CO 2 /95% humidified air

Treatment doses depend on the cause: pernicious anaemia typically requires intramuscular hydroxocobalamin 1,000 micrograms three times weekly initially, whilst dietary deficiency may be treated with oral cyanocobalamin 50150 micrograms or 1,000 micrograms daily

Ascorbate may also influence plant epigenetic processes (Ramakrishnan et al