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Peptides may be lower-risk in some situations because they often stimulate natural hormone pathways rather than directly replacing hormones

Cardiovascular outcome trials for liraglutide, semaglutide, and dulaglutide demonstrated modest blood pressure reductions alongside reduced major adverse cardiovascular events

Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes

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For this reason, doctors may recommend pairing GLP-1 receptor agonist treatment with a high-protein diet and strength training to maintain muscle mass