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butyrate is predominantly utilized by colonocytes, with only small amounts entering systemic circulation ( de novo lipogenesis (DNL) ( When intestinal barrier function is compromised, bacterial components such as LPS can enter the liver via the portal vein, triggering Toll-like receptor 4 (TLR4)-mediated inflammatory responses ( 3.2.2 Hepatic processing and distribution of gut-derived metabolites The liver, as the body's largest metabolic organ, possesses robust capabilities for substrate extraction and biotransformation

I'll try the supplements when a jab is due and see if that helps

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