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In 2019, ESC guidelines recommended the use of SGLT2 inhibitors or GLP-1 RAs as first-line drugs in CV patients at high or very high risk with T2DM who do not receive any glucose-lowering treatment and the addition to current glucose-lowering therapy of SGLT2 inhibitors or GLP-1 RAs in those patients regardless of glucose control (Figure 3),18

Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: effects on the lung miR-204 expression, remodeling, and inflammatory factors

McKenna Andrews, MD 1 , David W

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For example, the hydroxylation of proline and lysine residues in collagen by prolyl and lysyl hydroxylase enzymes requires Vitamin C as a cofactor