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Moreover, the regulation of sodium and calcium homeostasis in cardiomyocytes and coronary endothelium is directly translated into improved contractility and relaxation of the heart ( Diuretic and natriuretic effects of SGLT2 inhibitors contribute to the reduction of intravascular volume and decrease in blood pressure, lowering afterload, improving cardiac efficiency, and reducing ventricular mass index (Mazidi et al., 2017
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[58] have demonstrated that zinc deficiency suppresses Nrf2 activity in diabetes-induced renal oxidative damage in mice
119: Academic Press
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