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Description

Glutathione is often referred to as the "master antioxidant." Unlike glutamine, which is a single amino acid, glutathione is a tri-peptide

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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19