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For all experimental groups, treatments were administered in a counter-balanced, within-subject design and injection days were separated by 72 hours

1 Introduction As a core pathological feature of type 2 diabetes (T2DM) and metabolic syndrome, insulin resistance (IR) has become a major global public health challenge

Most of these side effects are mild and tend to decrease over time as the body adjusts to the medication

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A quintessential example is the burgeoning body of evidence demonstrating that reactive oxygen species (ROS) can serve as triggers for diverse forms of cell death collectively known as oxidative cell death