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As a result of these beneficial effects of GLP-1R activation on metabolism, several drugs acting on the GLP-1R have been developed for the treatment of T2DM and obesity, including the GLP-1RAs liraglutide and exendin-4 or its synthetic version exenatide, and additional products are in different stages of development (Nauck et al., 2016

TSTU (146.2 gm) was added to the reaction mixture at 25-30C and stirred for 15 min at the same temperature

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Since muscles contribute to energy expenditure at more than twice the rate of fat tissue, the reduction in muscle and other lean mass accompanying fat loss results in lower energy expenditure after weight reduction

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