Apply gentle pressure with a clean cotton pad if needed, but avoid rubbing the site vigorously, which can increase irritation and bruising risk
Factors such as baseline body composition, pre-existing thyroid function, nutritional status, and environmental temperature all influence whether a patient experiences cold sensitivity
Clinical approach recommendations include starting with the most conservative effective therapy, optimizing tirzepatide dosing before adding other agents, regular monitoring of cardiovascular parameters and metabolic markers, and setting realistic weight loss goals (5-10% initial target)
Researchers randomly assigned participants to 4mg, 9mg and 12mg dosing groups and a placebo group
doi: 10.3390/medicina57030200 589 NaculLAuthierFJScheibenbogenCLorussoLHellandIBMartinJAet al