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In fact, the profound ROS accumulation characteristic of sickle RBCs has been demonstrated to be mainly caused by NADPH oxidase, which is regulated by Rac GTPase [179]

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Protein stability KGN cells were treated with 100 g/ml cycloheximide (CHX) while overexpressing YTHDF1, and assayed by Western blot to detect SLC7A5 protein expression

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