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Activated MZF1 induces expression of the lysosomal cysteine cathepsins B and L [47, 48] and several other cancer relevant genes [46], and interestingly also the expression of cholesterol transporter NPC1 leading to metabolic switch from cholesterol synthesis to cholesterol uptake and linking invasiveness to cholesterol uptake [7]

According to the guidelines of the International Pediatric Sepsis Consensus Conference 104 , neonatal sepsis is defined as a clinical syndrome characterized by the presence of both infection and systemic inflammatory response syndrome (SIRS) and can cause severe neurological complications due to brain infection, as well as secondary hypoxemia resulting from septic shock, pulmonary hypertension and severe lung disease