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Two molecules of GSH are converted into oxidized GSH (GSSG) by GPX4 and phospholipid hydroperoxides are reduced to nontoxic phospholipid alcohols by GPX4 simultaneously, which prevents the accumulation of toxic lipid peroxides ( Figure 1 Ferroptosis is also regulated by glutamine and glutamate ( c activity can be inhibited by high extracellular concentrations of glutamate, consequently inducing ferroptosis