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Biochemistry 36, 1503515040

Biochemical Analysis Serum enzymes (creatine phosphokinase, CK

IV therapy can deliver much higher doses - sometimes 25 grams or more in one session

doi: 10.1210/en.2008-0345 67 OuyangQ.XuY.BanY.LiJ.CaiY.WuB.et al

PRODUCT FOCUS: PEPTIDES AND PROTEINS PROCESS FOCUS: FORMULATION/STABILITY WHO SHOULD READ: ANALYTICAL AND FORMULATION DEVELOPMENT, PROCESS DEVELOPMENT, QA/QC AND REGULATORY AFFAIRS KEYWORDS: FORCED DEGRADATION, PROTEIN DEGRADATION, OXIDATION, DISULFIDE SCRAMBLING, DEAMIDATION, AGGREGATION, HYDROLYSIS LEVEL: INTERMEDIATE Advances in analytical chemistry have identified many degradation pathways that can occur in recombinant protein therapeutics over time