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Moreover, the large clinical trials did not consider ethnic differences in people from different regions and how the coffee was prepared ( in vitro study showed that the antagonist activity of caffeine has adenosine A2AR-mediated growth-promoting effects on HCC cells associated with the MAPK and NF-kappa B pathways ( 2.7 Toxicity or adverse effects of caffeine Maternal caffeine intake during pregnancy is associated with an increased risk of childhood obesity

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