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When considering weight loss injections alongside methotrexate, several safety considerations warrant careful attention

We recommend you make an appointment to have your vitamin B12 dosage safely administered by a physician at a clinic, or in some cases, your pharmacist may also be able to administer the injection with no appointment necessary

No negative interaction [25]

The incidence of injection site itching specifically is generally mild to moderate in severity and tends to be transient, often resolving spontaneously within a few hours to a few days without requiring medical intervention