Zhang Y., Zou Z., Liu S., et al., EdaravoneLoaded Poly(Amino Acid) Nanogel Inhibits Ferroptosis for Neuroprotection in Cerebral Ischemia Injury, Asian Journal of Pharmaceutical Sciences 19 (2024): 100886
The catalytic core of tyrosinase is composed of H 2 L 2 tetramer, and its active center contains binuclear copper ions, which form a six-coordinated chelating structure through His61, His85, His94(CuA), His259, His263 and His296(CuB) ( 2+ is the key step to catalyze the oxidation of L-tyrosine to dopaquinone, which depends on the precise regulation of the hydrophobic environment in the active chamber ( CuA and CuB are connected by an oxygen bridge to form a rigid structure, required for catalytic activity
Controlled Release: Provides a sustained release mechanism, ensuring prolonged antioxidant protection and tyrosine inhibition
Finally, 400 L of PI was added for staining of 30 min at room temperature in the dark
doi: 10.1172/JCI59643 109 NeteaMGNold-PetryCANoldMFJoostenLAOpitzBvan der MeerJHet al
