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Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig

Atherosclerosis 163 , 1728 (2002)

Blood Glutathione levels (both reduced and oxidized forms) in the liquid portion of blood can act as a readout of systemic (whole body) OS (Anderson and Meister, 1980)

Conclusions Our study reveals the critical role of hepsin, a type II transmembrane serine protease, in protecting against APAP-induced liver injury by decreasing cellular GJ abundance in response to reactive oxygen stress in the liver

Subtle changes may appear around weeks 3 to 4