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doi: 10.1152/ajpcell.00043.2009 43 TaylorWEBhasinSArtazaJByhowerFAzamMWillardDHet al

However, most people find that the effects of this medication begin wearing off within a few weeks to months after the last dose

The triple receptor activation creates dramatic appetite suppression, increased energy expenditure, and preferential fat oxidation

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Patients typically begin with a lower starting dose (0.25 mg weekly for four weeks) to allow the body to adjust to the medication, reducing the likelihood of gastrointestinal side effects such as nausea or vomiting