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These sites already rely on products designated for investigational use and follow strict informed-consent, institutional review board (IRB), pharmacy and storage requirements

Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64

It is reported that both DA-JC4 and DA5-CH could improve STZ-induced learning and memory impairment, reduce levels of phosphorylated tau protein and STZ-induced chronic inflammation response in brain (233, 237)

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