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Meta-analytic data indicate that tinnitus patients with normal hearing thresholds often exhibit significantly reduced ABR wave-I amplitudes, consistent with synaptic loss, and an increased wave-V/I ratio, suggesting central gain enhancement, although changes in wave-V amplitude are inconsistent across studies 43,63

A meta-analysis of 56 studies examining MTHFR C677T in patients and control subjects indicated that the T allele and TT genotype carriers showed significant increased risk of major psychiatric disorders including schizophrenia and bipolar disorder 63

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Phytother Res 35(10):54405458 Goel F, Kumar D, Sharma A (2025) Impact of corticoid receptors on Alzheimers disease: a neuroendocrine perspective

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