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Underlying health conditions: Some health conditions, such as gastrointestinal disorders or liver disease, can affect B12 absorption and metabolism, potentially leading to shorter-lasting benefits from B12 injections

This was thought related to the rapid glucose lowering in patients with pre-existing diabetic retinopathy (a known phenomenon where quick improvement of blood sugar can transiently worsen retinopathy)

Adding 5g creatine to 2-3g of carnitine, together with carbohydrate should assist in loading of both nutrients

CHAC1 emerges as a key stress-responsive effector, transcriptionally upregulated via the ATF4-CHOP axis during endoplasmic reticulum stress and amino acid deprivation

(In essence, FOXO4 holds p53 so it cannot execute the death program)